Continuity: When the last guy dies as he tries to escape out the swimming pool window, a large amount of blood lands on the window. The shot cuts to Ricky looking worried, then the next shot shows Ricky leaving. In the background you can see that the blood on the window is now missing.

Factual error: The uniform the female soldier is wearing when she comes back home is all wrong: the camo pattern is that of the USMC digital desert uniform but it has "US ARMY" chest tags (in a strange size and position, by the way). The US flag and unit insignia are on the wrong arms. The cut of the jacket is ACU, the pants are true USMC.

Continuity: The birth of the Predalien in this movie is completely different than it was in the first AVP. The lights on the table are different and the Predalien bursts out differently than in the first film.

Continuity: When the guy with the predator gun shoots the gate at the end, so they go to the chopper, the wire fence keeps changing its shape in different shots.

Factual error: The nuclear device used at the climax of the film is shown to be dropped by an F-22 raptor however the designation used on the tactical display the "General" is looking at is for a much larger weapon that cannot be deployed by a fighter/bomber.

Factual error: During the scene where the helicopter leaves the hospital roof, a Canadian registration number is visible under the front doors. An aircraft which operates solely within the US, which is what would almost definitely happen for a city in Colorado, would legally have to have a US registration due to sabotage laws concerning the registration of aircraft. AVPR was filmed in British Columbia, Canada, which explains a Canadian registration number, since all Canadian aircraft registration begin with "C".