Continuity: Look carefully at the brochure Frank has about the Buffalo Chicken Wing festival, the building pictured is the same building as his daughter's school (seen earlier in the movie).

Deliberate "mistake": The 'NNN' news program shows a picture of some animal crackers in Frank's stomach. The problem is, they are still all in one piece and are pretty big. I don't think Frank would swallow them whole.

Continuity: When Drix freezes the witness from the ship, he says it will take a few days to wear off. Not even a day later it wears off and the witness is back to normal and runs off only to be frozen again later.

Audio problem: In the scene "By The Throat", After Osmosis goes down the escalator. The red air stuff starts to go around them. Osmosis moves his mouth but not until a couple seconds later when the shot changes do you hear what is that cherry stench.

Continuity: When Thrax enters the Hypothallimis, he kills one scientist, he then attacks the other scientist wearing glasses. When he picks up the scientist's glasses, there is tape holding them together in the middle, but when the glasses land on the ground, there isn't anything on the glasses at all.

Other: During the scene where Thrax is talking to the other germs and viruses in the Zit and is pointing out things on the map of Frank, the word 'collarbone' is spelled wrong ('Collerbone').

Continuity: When Frank drops his egg,it is almost all clean, but when he gets it up, it is dirty.

Factual error: A little problem with Thrax's plan: viruses, bacteria, etc. don't cause fevers themselves. That's the body's response to kill the parasites.